Kazuaki Takabe Selected Research

sphingosine kinase

1/2021	Sphingosine 1-phosphate (S1P) produced by sphingosine kinase 1 (SphK1) and exported via ABCC1 is related to hepatocellular carcinoma (HCC) progression.
12/2020	Sphingosine Kinase 1 is Associated With Immune Cell-Related Gene Expressions in Human Breast Cancer.
7/2019	Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation.
12/2018	Different Roles of Sphingosine Kinase 1 and 2 in Pancreatic Cancer Progression.
11/2018	Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
7/2018	Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis.
1/2018	TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.
1/2018	Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.
1/2018	ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer.
11/2017	Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.

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Kazuaki Takabe Research Topics

Disease

127	Neoplasms (Cancer) 11/2022 - 08/2008
94	Breast Neoplasms (Breast Cancer) 11/2022 - 08/2008
28	Neoplasm Metastasis (Metastasis) 08/2022 - 02/2012
18	Inflammation (Inflammations) 01/2021 - 01/2013
15	Triple Negative Breast Neoplasms 04/2022 - 01/2017
8	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 08/2010
8	Carcinogenesis 05/2021 - 08/2008
7	Stomach Neoplasms (Stomach Cancer) 01/2021 - 08/2008
6	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 10/2016
6	Colonic Neoplasms (Colon Cancer) 01/2021 - 08/2008
5	Lymphatic Metastasis 08/2021 - 05/2012
4	Microsatellite Instability 01/2021 - 10/2017
3	Hypoxia (Hypoxemia) 08/2022 - 01/2020
3	Hepatocellular Carcinoma (Hepatoma) 05/2021 - 09/2016
3	Cicatrix (Scar) 08/2020 - 07/2019
3	Adenocarcinoma 05/2020 - 01/2019
3	Colitis-Associated Neoplasms 11/2018 - 01/2013
3	Ulcerative Colitis 01/2016 - 01/2013
3	Colitis 01/2016 - 01/2014
2	Disease Progression 01/2022 - 09/2014
2	Pathologic Complete Response 01/2021 - 12/2020
2	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 03/2018
2	Pathologic Processes 04/2020 - 12/2016
2	Fibrosis (Cirrhosis) 09/2018 - 11/2016
2	Obesity 01/2018 - 11/2017
2	Anemia 12/2017 - 11/2012
2	Cholestasis 01/2017 - 11/2016
2	Liver Diseases (Liver Disease) 09/2016 - 11/2003

Drug/Important Bio-Agent (IBA)

41	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2021 - 08/2008
26	Biomarkers (Surrogate Marker)IBA 02/2022 - 08/2010
21	sphingosine kinaseIBA 01/2021 - 08/2008
19	LipidsIBA 12/2021 - 11/2011
14	SphingolipidsIBA 05/2021 - 07/2009
13	EnzymesIBA 11/2022 - 01/2017
13	Estrogen ReceptorsIBA 01/2022 - 02/2013
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2008
12	Pharmaceutical PreparationsIBA 01/2022 - 01/2014
9	MicroRNAs (MicroRNA)IBA 01/2021 - 10/2017
9	SphingosineIBA 12/2018 - 01/2014
8	Interleukin-6 (Interleukin 6)IBA 07/2022 - 01/2014
8	Messenger RNA (mRNA)IBA 01/2022 - 08/2008
8	Phosphotransferases (Kinase)IBA 01/2021 - 01/2014
8	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 10/2017
8	Fingolimod Hydrochloride (FTY720)FDA Link 01/2020 - 11/2011
7	Phenobarbital (Luminal)FDA Link 01/2022 - 01/2017
7	Biological ProductsIBA 01/2021 - 08/2008
6	Hormones (Hormone)IBA 11/2022 - 12/2018
6	RNA (Ribonucleic Acid)IBA 05/2021 - 01/2017
6	CytokinesIBA 01/2021 - 05/2013
5	InterferonsIBA 07/2022 - 09/2020
5	Estrogens (Estrogen)FDA Link 01/2022 - 01/2019
5	CeramidesIBA 05/2021 - 01/2016
5	human ERBB2 proteinIBA 10/2020 - 02/2013
4	Mechanistic Target of Rapamycin Complex 1IBA 07/2022 - 01/2021
4	Immune Checkpoint InhibitorsIBA 01/2021 - 12/2017
4	Sphingosine-1-Phosphate ReceptorsIBA 11/2017 - 11/2011
3	Complement System Proteins (Complement)IBA 07/2022 - 01/2021
3	AndrogensIBA 01/2022 - 03/2018
3	ErbB Receptors (EGF Receptor)IBA 01/2022 - 05/2013
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2021 - 11/2019
3	palbociclibIBA 01/2021 - 12/2018
3	ChemokinesIBA 01/2021 - 05/2013
3	Immune Checkpoint ProteinsIBA 01/2021 - 12/2020
3	Histones (Histone)IBA 09/2020 - 07/2019
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2018 - 02/2013
3	Bile Acids and Salts (Bile Acids)IBA 01/2017 - 01/2016
2	Small Interfering RNA (siRNA)IBA 11/2022 - 08/2020
2	Oxygen (Dioxygen)IBA 07/2022 - 01/2021
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 04/2022 - 11/2021
2	Interleukin-2 (IL2)IBA 01/2022 - 05/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2019
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2022 - 07/2020
2	A-Form DNA (A-DNA)IBA 11/2021 - 01/2021
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021 - 08/2019
2	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 05/2019
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2021 - 12/2020
2	NucleotidesIBA 01/2021 - 06/2020
2	Sorafenib (BAY 43-9006)FDA Link 01/2021 - 12/2020
2	Annexin A1IBA 01/2021 - 08/2019
2	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2020 - 11/2017
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2020 - 01/2019
2	Protein Isoforms (Isoforms)IBA 04/2020 - 01/2016
2	Everolimus FDA Link 01/2020 - 12/2018
2	Transforming Growth Factors (Transforming Growth Factor)IBA 07/2019 - 05/2013
2	PerforinIBA 07/2019 - 08/2018
2	Granzymes (Granzyme)IBA 07/2019 - 08/2018
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 05/2013
2	IsoenzymesIBA 01/2018 - 04/2010
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2017 - 02/2013
2	Epidermal Growth Factor (EGF)IBA 01/2017 - 08/2008
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2016 - 12/2015

Therapy/Procedure

34	Therapeutics 04/2022 - 08/2008
21	Neoadjuvant Therapy 11/2022 - 05/2019
16	Drug Therapy (Chemotherapy) 04/2022 - 08/2008
7	Immunotherapy 04/2022 - 01/2016
5	Precision Medicine 01/2022 - 12/2016
3	Radiotherapy 01/2022 - 09/2016
2	Adjuvant Chemotherapy 12/2019 - 01/2017
2	Radical Mastectomy 11/2018 - 11/2017
2	Mastectomy (Mammectomy) 11/2018 - 11/2017